5-Amino-1MQ
Inhibits Nicotinamide N-methyltransferase (NNMT), an enzyme that slows down the metabolism of fat cells. By inhibiting it, it increases NAD+ and energy expenditure.
- Loss of visceral fat
- Increased levels of NAD+ (Anti-Aging)
- Preservation of muscle mass
- No nervousness/tremorsLoss of visceral fat
- No nerves/tremors
- High production costs.
- Limited long-term safety data.
- Potential impact on methylation.High production cost.
- Potential impact on methylation.
5-Amino-1MQ is a selective inhibitor of the enzyme NNMT (Nicotinamide N-methyltransferase), a molecule that acts as a central regulator of cell metabolism and energy management in adipose and muscle tissues.
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What it is (in plain language)
- Imagine that cells have a 'brake' that prevents them from burning too much energy to save resources. 5-Amino-1MQ works by blocking this brake (the NNMT enzyme). By inhibiting this enzyme, the cell is forced to increase its metabolic rate, optimising the use of fat and increasing the production of NAD+, an essential molecule for longevity and cell repair.
Why do you appear online so much
- It is a favourite in the biohacking and longevity world because it is considered an 'exercise mimicker'. Reports suggest that it can help with visceral fat loss and increase muscle strength without the stimulating effects of common thermogenics, making it attractive for those looking for metabolic optimisation without cortisol spikes or insomnia.
How it is framed today (pragmatic view)
- 1) Evidence: The strongest data comes from animal and in vitro models showing significant reduction in fat mass and improvement in metabolic health; human data is still predominantly anecdotal or from early-stage trials. 2) Purpose: Focused almost exclusively on body recomposition and mitochondrial health. 3) Risk: As it alters methylation pathways, balance with methyl donors (such as B12 and Folate) should be monitored.
How to use this form
- See the scientific references section to understand the role of NNMT in ageing. This content is strictly educational.
- Quick profile (curated by Subject 157)
- Class: Metabolic
- Status: Verified
- Use case: Fat Loss
- Route: Oral
- Tags: Oral|Metabolic|Fat Loss
- Half-life: Unknown
- Start: Gradual
- Duration: Sustained
- Mechanism (high level)
Inhibits Nicotinamide N-methyltransferase (NNMT), an enzyme that slows down the metabolism of fat cells. By inhibiting it, it increases NAD+ and energy expenditure.
- Evidence (what the literature covers)
RESEARCH RANGE (Obesity, Non-prescriptive):
Studies in mice show a reduction in 30% fat mass.
Level of Evidence: C (Promising).
- Safety and harm-reduction (non-prescriptive)
Risks: High production costs.
Limited long-term safety data.
Potential impact on methylation.
Interactions: Methyl donors (TMG).
- References (anchors)
- Neelakantan, H. (2018) - NNMT inhibitor 5-amino-1MQ reverses diet-induced obesity (mouse) - https://doi.org/10.1016/j.bcp.2017.11.007
- PubMed:29155147
Note: Educational/research content. Does not constitute medical advice, diagnosis or prescription.
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