GHRP-6

The 'father' of GHRPs. Famous for inducing extreme hunger and secretion of gastric juices, in addition to the GH pulse.

Half-Life

~20-30 mins

Onset

Immediate

Duration

~2 hours

Route

Injectable

Mechanism of Action

Agonist of the ghrelin receptor. Mimics the 'hunger hormone', signalling the body to eat and grow. Strongly releases GH.

Key Benefits

Massive appetite stimulation (Bulking)
GH release
Gastric protection
Recovery from injuriesMassive appetite stimulation (Bulking)
Recovery from injuries

Evidence Notes

RESEARCH RANGE (Clinical/Vet, Non-prescriptive): Used to diagnose GH deficiency. Level of Evidence: A.

Risk Profile

Uncontrollable hunger (risk of obesity).
Insulin resistance.
Elevated prolactin.Uncontrollable hunger (risk of obesity).
Elevated prolactin.

Overview

GHRP-6 is a first generation peptide which, as well as stimulating the release of GH, acts as a potent mimic of ghrelin, the hormone responsible for the hunger signal and gastric motility.

What it is (in plain language)
- This peptide does two main things: it forces the body to release GH and 'activates' an extreme hunger signal in the brain. It also speeds up the emptying of the stomach, which makes it unique among GH secretagogues for its ability to directly influence the digestive system.

Why do you appear online so much
- It is the number one choice for bulking. Bodybuilders and patients struggling to gain weight use it specifically to be able to consume the calories needed for growth, while benefiting from the anabolic effect of high GH.

How it is framed today (pragmatic view)
- 1) Evidence: Decades of research and clinical use. 2) Purpose: Weight gain, accelerated recovery and treatment of gastroparesis. 3) Risk: The drastic increase in hunger and potential water retention are the main points of attention.

How to use this form
- Read about the effect on ghrelin to understand why this compound should not be used in aggressive fat loss protocols.

- Quick profile (curated by Subject 157)
- Class: Hormonal
- Status: Verified
- Use case: Muscle Growth
- Route: Injectable
- Tags: Injectable|GH|Appetite
- Half-life: ~20-30 mins
- Start: Immediate
- Duration: ~2 hours

- Mechanism (high level)
Agonist of the ghrelin receptor. Mimics the 'hunger hormone', signalling the body to eat and grow. Strongly releases GH.

- Evidence (what the literature covers)
RESEARCH RANGE (Clinical/Vet, Non-prescriptive):
Used to diagnose GH deficiency.
Level of Evidence: A.

- Safety and harm-reduction (non-prescriptive)
Risks: Uncontrollable hunger (risk of obesity).
Insulin resistance.
Elevated prolactin.
Interactions: Carbohydrates (reduces efficacy).

- References (anchors)
- Bercu, B. B. (1992) - GHRP-6 clinical studies - https://doi.org/10.1210/edrv-13-2-301
- Davenport, A. P. (2009) - GHRP-6 and ghrelin receptor pharmacology - https://doi.org/10.1371/journal.pone.0006334 | PubMed:19623253
- De Gennaro Colonna, V. (1998) - GHRP-6 cardiac protective effects - https://doi.org/10.1080/004982598238976 | PubMed:9814402

Note: Educational/research content. Does not constitute medical advice, diagnosis or prescription.

Scientific References

Bercu, B. B. (1992) - GHRP-6 clinical studies -

DOI

Davenport, A. P. (2009) - GHRP-6 and ghrelin receptor pharmacology -

PUBMED DOI

De Gennaro

Colonna, V. (1998) - GHRP-6 cardiac protective effects - B. B. (1992) - GHRP-6 clinical studies -

DOI

Colonna, V. (1998) - GHRP-6 cardiac protective effects -

PUBMED DOI

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