IGF-1 LR3

What it is (in plain language)
- If GH is the signaller, IGF-1 is the executor. This 'LR3' version remains active in your body for almost a whole day. Its main function is muscle hyperplasia (division and creation of new muscle fibres), something that exercise alone can rarely do as efficiently.

Why do you appear online so much
- It is considered the 'holy grail' of modern anabolism. While other peptides help existing cells grow, IGF-1 LR3 helps create new cells, making it extremely popular in elite protocols for radically changing body composition.

How it is framed today (pragmatic view)
- 1) Evidence: Originally used to treat growth failure, with extensive literature on cell proliferation. 2) Objective: Localised and systemic muscle growth. 3) Risk: Can cause hypoglycaemia and, as it is a potent growth factor, should never be used in the presence of neoplasms.

How to use this form
- Carefully analyse the 'Storage' and 'Interactions' section due to the glycaemic sensitivity that this compound causes.

- Quick profile (curated by Subject 157)
- Class: Hormonal
- Status: Verified
- Use case: Hormonal
- Route: Injectable
- Tags: Injectable|Muscle|Anabolic
- Half-life: ~20-30 Hours
- Start: Fast
- Duration: ~24 hours

- Mechanism (high level)
Analogue of IGF-1 with a substitution (Arg) and an N-terminal extension. It has a reduced affinity for binding proteins (IGFBPs), keeping it active in the blood for much longer.

- Evidence (what the literature covers)
RESEARCH RANGE (Non-prescriptive):
Doses of 20mcg to 50mcg (post-workout or daily).
Level of Evidence: B.

- Safety and harm-reduction (non-prescriptive)
Risks: Hypoglycaemia (dangerous), growth of existing polyps/tumours, distended gut.
Interactions: Insulin (double risk).

- References (anchors)
- Conlon, M. A. (1995) - Long R3 IGF-I as potent IGF analogue in vivo - https://doi.org/10.1677/joe.0.1460247
- PubMed:7616161

Note: Educational/research content. Does not constitute medical advice, diagnosis or prescription.