MOTS-c

What it is (in plain language)
- Imagine MOTS-c as a 'messenger' that your mitochondria send to the rest of the body to tell it to burn sugar and fat more efficiently. It mimics many of the metabolic benefits of intense physical exercise, protecting cells against metabolic stress.

Why do you appear online so much
- It is hailed as the 'exercise peptide'. Biohackers use it to increase physical endurance, combat insulin resistance and promote longevity by optimising the cells' energy plants (mitochondria).

How it is framed today (pragmatic view)
- 1) Evidence: Cutting-edge research in mitochondrial biology with excellent results in longevity models. 2) Objective: Metabolic flexibility and sports performance. 3) Risk: High safety profile; the focus should be on the purity of the compound.

How to use this form
- See the references on the activation of the AMPK pathway.

- Quick profile (curated by Subject 157)
- Class: Metabolic
- Status: Verified
- Use case: Metabolic
- Route: Injectable
- Tags: Injectable|Metabolic|Endurance
- Half-life: Unknown
- Start: Fast
- Duration: Variable

- Mechanism (high level)
Mitochondria-derived peptide (MDP). Regulates the folate cycle and glucose metabolism, increasing insulin sensitivity and fatty acid oxidation.

- Evidence (what the literature covers)
RESEARCH RANGE (Non-prescriptive):
Doses from 5mg to 10mg (frequency varies). It hurts to inject.
Level of Evidence: C (Recent studies).

- Safety and harm-reduction (non-prescriptive)
Risks: Pain on injection (common).
Possible local reaction.
Interactions: Unknown.

- References (anchors)
- Lee, C. (2015) - MOTS-c prevents insulin resistance - https://doi.org/10.1016/j.cmet.2015.02.009 | PubMed:25738459
- Kim, K. H. (2018) - MOTS-c promotes metabolic homeostasis - https://doi.org/10.1016/j.cmet.2018.06.008 | PubMed:29979015

Note: Educational/research content. Does not constitute medical advice, diagnosis or prescription.