{"id":2159,"date":"2025-12-11T04:11:01","date_gmt":"2025-12-11T04:11:01","guid":{"rendered":"https:\/\/subject157.com\/?p=2159"},"modified":"2025-12-11T05:15:31","modified_gmt":"2025-12-11T05:15:31","slug":"epitalon-e-a-modulacao-telomerica-evidencia-pre-clinica-em-longevidade-ritmos-circadianos-e-estabilidade-genomica-2025","status":"publish","type":"post","link":"https:\/\/subject157.com\/fr\/epitalon-et-modulation-des-telomeres-preuves-precliniques-de-la-longevite-rythmes-circadiens-et-stabilite-genomique-2025\/","title":{"rendered":"Epitalon et modulation t\u00e9lom\u00e9rique : preuves pr\u00e9cliniques en mati\u00e8re de long\u00e9vit\u00e9, de rythmes circadiens et de stabilit\u00e9 g\u00e9nomique (2025)"},"content":{"rendered":"<h2 class=\"wp-block-heading\">R\u00e9sum\u00e9<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">L'\u00e9pitalon (\u00e9pithalamine\/\u00e9pithalon) est un t\u00e9trapeptide (Ala-Glu-Asp-Gly) isol\u00e9 \u00e0 l'origine \u00e0 partir de la glande pin\u00e9ale. Des \u00e9tudes men\u00e9es entre 1971 et 2020 sugg\u00e8rent que ce peptide module l'activit\u00e9 de la t\u00e9lom\u00e9rase, r\u00e9tablit les rythmes circadiens, r\u00e9duit les dommages oxydatifs et affecte l'expression g\u00e9n\u00e9tique associ\u00e9e au vieillissement. Dans des mod\u00e8les animaux, l'Epitalon a d\u00e9montr\u00e9 des augmentations constantes de la \u00ab dur\u00e9e de vie en bonne sant\u00e9 \u00bb et de la dur\u00e9e de vie moyenne. Cette revue consolide les preuves existantes, en se concentrant sur les m\u00e9canismes biologiques et les \u00e9tudes pr\u00e9cliniques de Khavinson et Anisimov.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">1. Introduction<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">L'Epitalon est l'un des compos\u00e9s les plus \u00e9tudi\u00e9s dans le domaine des <em>g\u00e9roprotecteurs<\/em>, avec des d\u00e9cennies de donn\u00e9es provenant de :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Mod\u00e8les animaux<\/li>\n\n\n\n<li>Cultures cellulaires<\/li>\n\n\n\n<li>\u00c9tudes \u00e0 petite \u00e9chelle chez l'homme<\/li>\n\n\n\n<li>Essais cliniques sovi\u00e9tiques et post-sovi\u00e9tiques<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Il a \u00e9t\u00e9 initialement d\u00e9riv\u00e9 de l'extrait pin\u00e9al. <strong>\u00c9pithalamine<\/strong>, puis synth\u00e9tis\u00e9 sous forme de t\u00e9trapeptide pur.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Principaux domaines de recherche :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Activation de la t\u00e9lom\u00e9rase<\/li>\n\n\n\n<li>Stabilisation des t\u00e9lom\u00e8res<\/li>\n\n\n\n<li>R\u00e9gulation du rythme circadien<\/li>\n\n\n\n<li>Normalisation de la m\u00e9latonine<\/li>\n\n\n\n<li>Immunomodulation l\u00e9g\u00e8re<\/li>\n\n\n\n<li>Antioxydant syst\u00e9mique indirect<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">2. M\u00e9canismes biologiques fondamentaux<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">2.1 Activation de la t\u00e9lom\u00e9rase et maintien des t\u00e9lom\u00e8res<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">L'un des effets les plus \u00e9tudi\u00e9s.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Epitalon :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Augmente l'expression de la <strong>t\u00e9lom\u00e9rase reverse transcriptase (TERT)<\/strong><\/li>\n\n\n\n<li>R\u00e9duit le taux de raccourcissement des t\u00e9lom\u00e8res<\/li>\n\n\n\n<li>Favorise une r\u00e9plication cellulaire plus stable<\/li>\n\n\n\n<li>Il a montr\u00e9 qu'il \u00e9tait possible de restaurer les t\u00e9lom\u00e8res dans des fibroblastes vieillis in vitro.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Khavinson (2003) a d\u00e9montr\u00e9 :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Augmentation des t\u00e9lom\u00e8res dans 33% dans une culture cellulaire expos\u00e9e \u00e0 l'Epitalon.<\/li>\n\n\n\n<li>Effets cumulatifs et d\u00e9pendants de la dur\u00e9e d'exposition.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">2.2 Stabilisation du rythme circadien et m\u00e9latonine<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Epitalon a d\u00e9montr\u00e9 :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Normaliser les rythmes circadiens chez les mod\u00e8les animaux \u00e2g\u00e9s<\/li>\n\n\n\n<li>Augmenter la m\u00e9latonine nocturne<\/li>\n\n\n\n<li>R\u00e9duire les distorsions du cycle clair-fonc\u00e9<\/li>\n\n\n\n<li>Am\u00e9liorer l'efficacit\u00e9 du sommeil (donn\u00e9es observationnelles chez l'homme)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Anisimov (2000) a rapport\u00e9 :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Correction partielle de l'amplitude de la m\u00e9latonine chez les animaux \u00e2g\u00e9s<\/li>\n\n\n\n<li>Am\u00e9lioration du rythme locomoteur nocturne<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">2.3 Signalisation \u00e9pig\u00e9n\u00e9tique et modulation de l'expression g\u00e9n\u00e9tique<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Des \u00e9tudes transcriptomiques indiquent :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Upregulation des g\u00e8nes impliqu\u00e9s dans la r\u00e9paration de l'ADN<\/li>\n\n\n\n<li>Downregulation des g\u00e8nes pro-inflammatoires<\/li>\n\n\n\n<li>Normalisation des g\u00e8nes circadiens tels que <strong>PER1<\/strong>, <strong>CLOCK<\/strong>, <strong>BMAL1<\/strong><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Epitalon agit comme un <em>peptide signaleur<\/em> qui module l'expression, sans ins\u00e9rer de mat\u00e9riel g\u00e9n\u00e9tique.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">2.4 R\u00e9duction du stress oxydatif et des dommages accumul\u00e9s<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Epitalon a d\u00e9montr\u00e9 :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>R\u00e9duction de la lipoperoxydation<\/li>\n\n\n\n<li>Moins de ROS produits<\/li>\n\n\n\n<li>Am\u00e9lioration des enzymes antioxydantes endog\u00e8nes (SOD, catalase)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Ces effets semblent \u00eatre secondaires \u00e0 l'am\u00e9lioration de :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Rythme circadien<\/li>\n\n\n\n<li>Hom\u00e9ostasie m\u00e9tabolique<\/li>\n\n\n\n<li>Efficacit\u00e9 de la r\u00e9paration cellulaire<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">2.5 Immunomodulation l\u00e9g\u00e8re<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Les observations comprennent :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Augmentation mod\u00e9r\u00e9e de l'activit\u00e9 des cellules NK<\/li>\n\n\n\n<li>Am\u00e9lioration de la r\u00e9ponse immunitaire chez les animaux \u00e2g\u00e9s<\/li>\n\n\n\n<li>R\u00e9duction de l'inflammation basale<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">3. \u00c9tudes pr\u00e9cliniques sur la long\u00e9vit\u00e9<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">3.1 \u00c9tudes d'Anisimov (1999-2003)<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Chez les rats et les souris, les r\u00e9sultats ont montr\u00e9 :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Augmentation de <strong>11\u201327%<\/strong> dans la vie moyenne<\/li>\n\n\n\n<li>R\u00e9duction de l'incidence des tumeurs spontan\u00e9es<\/li>\n\n\n\n<li>Am\u00e9lioration des marqueurs m\u00e9taboliques associ\u00e9s \u00e0 l'\u00e2ge<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Ces \u00e9tudes sont souvent cit\u00e9es comme preuve de l'action g\u00e9roprotectrice.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">3.2 Essais avec l'\u00e9pithalamine (extrait pin\u00e9al)<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Avant l'Epitalon synth\u00e9tique :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>La dur\u00e9e de vie moyenne a augment\u00e9 jusqu'\u00e0 25%<\/li>\n\n\n\n<li>Am\u00e9lioration notable des rythmes circadiens<\/li>\n\n\n\n<li>Moins de maladies cardiovasculaires<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Bien que difficiles \u00e0 reproduire, ils ont \u00e9t\u00e9 constants pendant des d\u00e9cennies de recherche sovi\u00e9tique.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">3.3 \u00c9tudes modernes sur la culture cellulaire<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Des donn\u00e9es r\u00e9centes montrent que :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Restauration de la division dans les fibroblastes s\u00e9nescents<\/li>\n\n\n\n<li>R\u00e9duction des dommages oxydatifs dans les cellules neuronales<\/li>\n\n\n\n<li>Effets d\u00e9pendants de la dose et de la dur\u00e9e d'exposition<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">4. Biodisponibilit\u00e9 et pharmacodynamique<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Propri\u00e9t\u00e9s :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Petit t\u00e9trapeptide \u2192 bonne diffusion<\/li>\n\n\n\n<li>Action syst\u00e9mique et locale<\/li>\n\n\n\n<li>Demi-vie relativement courte (quelques minutes seulement)<\/li>\n\n\n\n<li>Effets prolong\u00e9s dus \u00e0 la signalisation \u00e9pig\u00e9n\u00e9tique<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">La demi-vie courte ne limite pas la fonction, car Epitalon agit comme un \u00ab d\u00e9clencheur \u00bb et non comme un agoniste continu.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">5. Applications dans la recherche<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">5.1 Biog\u00e9rontologie<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Ligne centrale d'int\u00e9r\u00eat :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>T\u00e9lom\u00e8res<\/li>\n\n\n\n<li>Rythmes circadiens<\/li>\n\n\n\n<li>R\u00e9paration de l'ADN<\/li>\n\n\n\n<li>Hom\u00e9ostasie endocrinienne li\u00e9e \u00e0 la glande pin\u00e9ale<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">5.2 Sommeil et rythmes biologiques<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Rapports d'observation :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Am\u00e9lioration de la latence du sommeil<\/li>\n\n\n\n<li>Sommeil plus profond<\/li>\n\n\n\n<li>Stabilisation des cycles circadiens irr\u00e9guliers<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">5.3 Stress oxydatif<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">R\u00e9duction constante de :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>ROS<\/li>\n\n\n\n<li>Lipoperoxydation<\/li>\n\n\n\n<li>Marqueurs de dommages mitochondriaux<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">5.4 R\u00e9g\u00e9n\u00e9ration et r\u00e9paration<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Les mod\u00e8les animaux sugg\u00e8rent :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>R\u00e9cup\u00e9ration tissulaire plus efficace<\/li>\n\n\n\n<li>R\u00e9duction de l'inflammation post-traumatique<\/li>\n\n\n\n<li>Augmentation de la r\u00e9sistance au stress cellulaire<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">6. S\u00e9curit\u00e9, effets secondaires et contre-indications<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Profil observ\u00e9<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Epitalon pr\u00e9sente l'un des profils les plus propres de la litt\u00e9rature pr\u00e9clinique.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Effets signal\u00e9s :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>L\u00e9g\u00e8re somnolence<\/li>\n\n\n\n<li>Maux de t\u00eate occasionnels<\/li>\n\n\n\n<li>Sensation de chaleur<\/li>\n\n\n\n<li>Augmentation des r\u00eaves vivants<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">Contre-indications th\u00e9oriques<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Tumeurs d\u00e9pendantes de la t\u00e9lom\u00e9rase<\/li>\n\n\n\n<li>Troubles prolif\u00e9ratifs<\/li>\n\n\n\n<li>Grossesse \/ allaitement<\/li>\n\n\n\n<li>Personnes souffrant de troubles circadiens graves sans \u00e9valuation m\u00e9dicale<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">Consid\u00e9rations suppl\u00e9mentaires<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">La modulation de la t\u00e9lom\u00e9rase est extr\u00eamement sensible et comporte des risques th\u00e9oriques.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Bien que les \u00e9tudes sovi\u00e9tiques n'aient pas signal\u00e9 d'augmentation des cas de cancer, l'extrapolation \u00e0 l'\u00eatre humain reste incertaine.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">7. Conclusion<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">L'\u00e9pitalon est l'un des peptides les plus \u00e9tudi\u00e9s dans le domaine de la long\u00e9vit\u00e9, avec des m\u00e9canismes solides dans :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Activation de la t\u00e9lom\u00e9rase<\/li>\n\n\n\n<li>Stabilisation des rythmes circadiens<\/li>\n\n\n\n<li>R\u00e9duction du stress oxydatif<\/li>\n\n\n\n<li>Modulation de l'expression g\u00e9n\u00e9tique<\/li>\n\n\n\n<li>Am\u00e9lioration des marqueurs physiologiques associ\u00e9s au vieillissement<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Les \u00e9tudes chez l'animal sont coh\u00e9rentes, mais les preuves cliniques modernes chez l'homme restent limit\u00e9es. L'\u00e9pitalon reste un candidat int\u00e9ressant pour la recherche en biog\u00e9rontologie, avec une base mol\u00e9culaire solide et un historique exp\u00e9rimental pertinent.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div class=\"wp-block-group subject157-references is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-group subject157-references is-layout-constrained wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading\">R\u00e9f\u00e9rences<\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Khavinson et al. (2003). <em>R\u00e9gulation peptidique de l'activit\u00e9 t\u00e9lom\u00e9rase.<\/em> Bulletin de biologie exp\u00e9rimentale et de m\u00e9decine.<\/li>\n\n\n\n<li>Anisimov et al. (1999). <em>Effets de l'Epitalon sur la dur\u00e9e de vie des rongeurs.<\/em> M\u00e9canismes du vieillissement et du d\u00e9veloppement.<\/li>\n\n\n\n<li>Khavinson &amp; Linkova (2016). <em>Peptides pin\u00e9aux et r\u00e9gulation circadienne.<\/em> Lettres de neuroendocrinologie.<\/li>\n\n\n\n<li>Ostanin et al. (2018). <em>Epitalon et modulation du stress oxydatif.<\/em> Biochimie (Moscou).<\/li>\n\n\n\n<li>Khavinson et al. (2000). <em>\u00c9pithalamine et biomarqueurs du vieillissement.<\/em> G\u00e9rontologie exp\u00e9rimentale.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>Synth\u00e8se scientifique sur l'Epitalon, y compris ses effets sur la t\u00e9lom\u00e9rase, les rythmes circadiens, l'expression g\u00e9n\u00e9tique et les \u00e9tudes pr\u00e9cliniques sur la long\u00e9vit\u00e9 men\u00e9es par Khavinson et Anisimov.<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[10],"tags":[74,70,57,67,56,69,72,53,73,75,58,71,68],"class_list":["post-2159","post","type-post","status-publish","format-standard","hentry","category-journal","tag-biogerontologia","tag-biomarcadores-de-idade","tag-envelhecimento-celular","tag-epitalon","tag-longevidade","tag-melatonina","tag-pineal","tag-reparacao-de-dna","tag-ritmo-circadiano","tag-sirtuinas","tag-stress-oxidativo","tag-telomerase","tag-telomeros"],"acf":[],"_links":{"self":[{"href":"https:\/\/subject157.com\/fr\/wp-json\/wp\/v2\/posts\/2159","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/subject157.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/subject157.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/subject157.com\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/subject157.com\/fr\/wp-json\/wp\/v2\/comments?post=2159"}],"version-history":[{"count":0,"href":"https:\/\/subject157.com\/fr\/wp-json\/wp\/v2\/posts\/2159\/revisions"}],"wp:attachment":[{"href":"https:\/\/subject157.com\/fr\/wp-json\/wp\/v2\/media?parent=2159"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/subject157.com\/fr\/wp-json\/wp\/v2\/categories?post=2159"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/subject157.com\/fr\/wp-json\/wp\/v2\/tags?post=2159"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}