{"id":2163,"date":"2025-12-11T04:13:22","date_gmt":"2025-12-11T04:13:22","guid":{"rendered":"https:\/\/subject157.com\/?p=2163"},"modified":"2025-12-19T03:04:34","modified_gmt":"2025-12-19T03:04:34","slug":"semax-e-a-modulacao-das-vias-melanocortinas-evidencia-em-neuroprotecao-bdnf-e-plasticidade-cognitiva-2025","status":"publish","type":"post","link":"https:\/\/subject157.com\/pl\/semax-i-modulacja-szlakow-melanokortyny-dowody-w-neuroprotekcji-bdnf-i-plastycznosci-poznawczej-2025\/","title":{"rendered":"Semax i modulacja szlak\u00f3w melanokortyny: dowody na neuroprotekcj\u0119, BDNF i plastyczno\u015b\u0107 poznawcz\u0105 (2025)"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"2163\" class=\"elementor elementor-2163\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-66ee1ad3 e-flex e-con-boxed e-con e-parent\" data-id=\"66ee1ad3\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-78200023 elementor-widget elementor-widget-text-editor\" data-id=\"78200023\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\n<h2 class=\"wp-block-heading\">Streszczenie<\/h2>\n\n\n\n<p>Semax \u00e9 um heptapept\u00eddeo derivado de ACTH(4\u20137), modificado para potenciar efeitos neuromodulat\u00f3rios sem ativa\u00e7\u00e3o adrenal perif\u00e9rica. Estudos publicados entre 1990 e 2024 demonstram que Semax aumenta a express\u00e3o de BDNF, modula vias melanocortinas, confere neuroprote\u00e7\u00e3o contra hip\u00f3xia\/isquemia e melhora par\u00e2metros de aten\u00e7\u00e3o, mem\u00f3ria e processamento cognitivo. Esta revis\u00e3o compila evid\u00eancia cl\u00ednica e pr\u00e9-cl\u00ednica, organizando os mecanismos biol\u00f3gicos centrais e resultados experimentais.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">1. Introdu\u00e7\u00e3o<\/h2>\n\n\n\n<p>Semax foi desenvolvido no Instituto de Investiga\u00e7\u00e3o Biom\u00e9dica da R\u00fassia como:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u015arodek neuroprotekcyjny<\/li>\n\n\n\n<li>Modulator poznawczy<\/li>\n\n\n\n<li>Regulador de stress neuroend\u00f3crino<\/li>\n<\/ul>\n\n\n\n<p>\u00c9 derivado do fragmento ACTH(4\u20137) com uma modifica\u00e7\u00e3o Pro-Gly-Pro que aumenta estabilidade e prolonga a\u00e7\u00e3o central.<\/p>\n\n\n\n<p>Ao contr\u00e1rio da ACTH completa:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>N\u00e3o<\/strong> stymuluje kortyzol<\/li>\n\n\n\n<li><strong>N\u00e3o<\/strong> ativa eixo HPA de forma sist\u00e9mica<\/li>\n\n\n\n<li>Atua predominantemente a n\u00edvel neurol\u00f3gico<\/li>\n<\/ul>\n\n\n\n<p>U\u017cywany eksperymentalnie w:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>D\u00e9fices cognitivos<\/li>\n\n\n\n<li>Recupera\u00e7\u00e3o ap\u00f3s hip\u00f3xia\/isquemia<\/li>\n\n\n\n<li>Aumento de aten\u00e7\u00e3o executiva<\/li>\n\n\n\n<li>Stany stresowe<\/li>\n\n\n\n<li>Plastyczno\u015b\u0107 neuron\u00f3w<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">2. Mecanismos Biol\u00f3gicos Fundamentais<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">2.1 Szlak melanokortyny (MC4R i MC5R)<\/h3>\n\n\n\n<p>Semax wsp\u00f3\u0142dzia\u0142a z:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Receptory melanokortyny MC4R<\/li>\n\n\n\n<li>Receptory melanokortyny MC5R<\/li>\n<\/ul>\n\n\n\n<p>Efekty:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Zwi\u0119kszona kontrolowana pobudliwo\u015b\u0107 neuron\u00f3w<\/li>\n\n\n\n<li>Regula\u00e7\u00e3o do equil\u00edbrio glutamato\/GABA<\/li>\n\n\n\n<li>Modula\u00e7\u00e3o da resposta ao stress<\/li>\n<\/ul>\n\n\n\n<p>A via melanocortina \u00e9 cr\u00edtica para:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Poznanie<\/li>\n\n\n\n<li>Humor<\/li>\n\n\n\n<li>Neuroplastyczno\u015b\u0107<\/li>\n\n\n\n<li>Homeostase auton\u00f3mica<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">2.2 Zwi\u0119kszona regulacja BDNF (najbardziej sp\u00f3jny efekt)<\/h3>\n\n\n\n<p>BDNF (czynnik neurotroficzny pochodzenia m\u00f3zgowego):<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Suporta crescimento e sobreviv\u00eancia neuronal<\/li>\n\n\n\n<li>Modula forma\u00e7\u00e3o de sinapses<\/li>\n\n\n\n<li>Aumenta aprendizagem e consolida\u00e7\u00e3o de mem\u00f3ria<\/li>\n<\/ul>\n\n\n\n<p>Badania pokazuj\u0105:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u2191 BDNF em c\u00f3rtex pr\u00e9-frontal<\/li>\n\n\n\n<li>\u2191 BDNF em hipocampo<\/li>\n\n\n\n<li>\u2191 express\u00e3o de NGF em alguns modelos<\/li>\n<\/ul>\n\n\n\n<p>Estes efeitos ocorrem mesmo em administra\u00e7\u00f5es de curta dura\u00e7\u00e3o.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">2.3 Plasticidade sin\u00e1ptica<\/h3>\n\n\n\n<p>Semax ativa m\u00faltiplas vias:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>ERK<\/li>\n\n\n\n<li>CREB<\/li>\n\n\n\n<li>PI3K<\/li>\n\n\n\n<li>mTOR (\u0142agodne i zale\u017cne od dawki)<\/li>\n<\/ul>\n\n\n\n<p>Consequ\u00eancias:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Potencia\u00e7\u00e3o de mem\u00f3ria de trabalho<\/li>\n\n\n\n<li>Ulepszona nauka przestrzenna<\/li>\n\n\n\n<li>Aumento de sinaptog\u00e9nese<\/li>\n\n\n\n<li>Recupera\u00e7\u00e3o p\u00f3s-stress<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">2.4 Neuroprote\u00e7\u00e3o contra hip\u00f3xia e isquemia<\/h3>\n\n\n\n<p>Semax demonstrou proteger neur\u00f3nios em modelos de:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Interrup\u00e7\u00e3o de fluxo sangu\u00edneo<\/li>\n\n\n\n<li>Encefalopatia hip\u00f3xica<\/li>\n\n\n\n<li>Stres oksydacyjny<\/li>\n\n\n\n<li>Inflama\u00e7\u00e3o induzida<\/li>\n<\/ul>\n\n\n\n<p>Mechanizmy te obejmuj\u0105:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Redu\u00e7\u00e3o de ROS<\/li>\n\n\n\n<li>Wzrost poziomu enzym\u00f3w antyoksydacyjnych<\/li>\n\n\n\n<li>Regula\u00e7\u00e3o de glutamato<\/li>\n\n\n\n<li>Inibi\u00e7\u00e3o de apoptose precoce<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">2.5 Regula\u00e7\u00e3o da resposta ao stress<\/h3>\n\n\n\n<p>Semax:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Reduz impacto da hiperativa\u00e7\u00e3o do eixo HPA<\/li>\n\n\n\n<li>Pode normalizar n\u00edveis de ansiedade induzida<\/li>\n\n\n\n<li>Melhora aten\u00e7\u00e3o sustentada em ambientes stressantes<\/li>\n<\/ul>\n\n\n\n<p>Estudos observacionais mostram melhoria de desempenho cognitivo sob press\u00e3o.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">3. Evid\u00eancia Pr\u00e9-Cl\u00ednica e Cl\u00ednica<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">3.1 Badania poznawcze<\/h3>\n\n\n\n<p>Ulepszenia widoczne w:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Szybko\u015b\u0107 przetwarzania<\/li>\n\n\n\n<li>Aten\u00e7\u00e3o executiva<\/li>\n\n\n\n<li>Mem\u00f3ria de trabalho<\/li>\n\n\n\n<li>Wydajno\u015b\u0107 w z\u0142o\u017conych zadaniach wizualnych<\/li>\n\n\n\n<li>Estados p\u00f3s-stress agudo<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">3.2 Estudos em les\u00e3o cerebral<\/h3>\n\n\n\n<p>Wykazano modele niedokrwienia:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Redu\u00e7\u00e3o de perda neuronal<\/li>\n\n\n\n<li>Recupera\u00e7\u00e3o funcional acelerada<\/li>\n\n\n\n<li>Redu\u00e7\u00e3o de inflama\u00e7\u00e3o glial<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">3.3 Estudos em idade avan\u00e7ada<\/h3>\n\n\n\n<p>Benef\u00edcios:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Melhoria de mem\u00f3ria epis\u00f3dica<\/li>\n\n\n\n<li>Aumento de motiva\u00e7\u00e3o e energia mental<\/li>\n\n\n\n<li>Redu\u00e7\u00e3o de \u201cslowing\u201d cognitivo<\/li>\n<\/ul>\n\n\n\n<p>Efeitos atribu\u00eddos a aumento de BDNF + melhoria sin\u00e1ptica.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">4. Biodisponibilidade e Farmacodin\u00e2mica<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Administra\u00e7\u00e3o t\u00edpica em investiga\u00e7\u00e3o: intranasal<\/li>\n\n\n\n<li>Absor\u00e7\u00e3o atrav\u00e9s da l\u00e2mina cribiforme<\/li>\n\n\n\n<li>A\u00e7\u00e3o central r\u00e1pida<\/li>\n\n\n\n<li>Semi-vida: estimada 12\u201320 minutos<\/li>\n\n\n\n<li>Efeitos prolongados via cascatas de sinaliza\u00e7\u00e3o<\/li>\n<\/ul>\n\n\n\n<p>Nawet przy kr\u00f3tkim okresie p\u00f3\u0142trwania wp\u0142ywa na godziny plastyczno\u015bci.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">5. Aplica\u00e7\u00f5es em Investiga\u00e7\u00e3o<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">5.1 Cogni\u00e7\u00e3o e performance intelectual<\/h3>\n\n\n\n<p>\u00c1reas onde Semax mostrou efic\u00e1cia:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Przyspieszona nauka<\/li>\n\n\n\n<li>Tarefas de aten\u00e7\u00e3o sustentada<\/li>\n\n\n\n<li>Wysokie obci\u0105\u017cenie poznawcze<\/li>\n\n\n\n<li>Execu\u00e7\u00e3o sob stress<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">5.2 Neuroprote\u00e7\u00e3o<\/h3>\n\n\n\n<p>Badania sugeruj\u0105, \u017ce Semax:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Zmniejsza apoptoz\u0119<\/li>\n\n\n\n<li>Protege contra hipoperfus\u00e3o<\/li>\n\n\n\n<li>Melhora recupera\u00e7\u00e3o motora<\/li>\n\n\n\n<li>Stabilizuje reaktywne mikroglej<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">5.3 Sa\u00fade mental e ansiedade<\/h3>\n\n\n\n<p>Observa\u00e7\u00f5es:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Redu\u00e7\u00e3o de ansiedade leve a moderada<\/li>\n\n\n\n<li>Lepszy nastr\u00f3j w stresuj\u0105cych sytuacjach<\/li>\n\n\n\n<li>Zwi\u0119kszona zdolno\u015b\u0107 koncentracji<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">6. Seguran\u00e7a, Efeitos Secund\u00e1rios e Contraindica\u00e7\u00f5es<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Og\u00f3lnie dobrze tolerowane<\/h3>\n\n\n\n<p>Opisane efekty:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Irrita\u00e7\u00e3o nasal leve<\/li>\n\n\n\n<li>\u0141agodny b\u00f3l g\u0142owy<\/li>\n\n\n\n<li>Estimula\u00e7\u00e3o mental excessiva em doses elevadas<\/li>\n\n\n\n<li>Ins\u00f3nia caso usado demasiado tarde<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">Contraindica\u00e7\u00f5es te\u00f3ricas<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Padaczka (z powodu zwi\u0119kszonej pobudliwo\u015bci)<\/li>\n\n\n\n<li>Estados psic\u00f3ticos ou man\u00edacos<\/li>\n\n\n\n<li>Gravidez\/lacta\u00e7\u00e3o (dados inexistentes)<\/li>\n\n\n\n<li>Dist\u00farbios de ansiedade severa sem supervis\u00e3o<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">7. Conclus\u00e3o<\/h2>\n\n\n\n<p>Semax \u00e9 um dos compostos mais profundamente estudados no campo da neuromodula\u00e7\u00e3o pept\u00eddica. A evid\u00eancia indica efeitos robustos em:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>BDNF<\/li>\n\n\n\n<li>Plastyczno\u015b\u0107 synaptyczna<\/li>\n\n\n\n<li>Neuroprotekcja<\/li>\n\n\n\n<li>Fun\u00e7\u00e3o cognitiva<\/li>\n\n\n\n<li>Resist\u00eancia ao stress<\/li>\n<\/ul>\n\n\n\n<p>Embora falte investiga\u00e7\u00e3o ocidental em larga escala, os resultados dos \u00faltimos 30 anos mostram um perfil promissor para estudos explorat\u00f3rios em neuroci\u00eancia aplicada.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div class=\"wp-block-group subject157-references is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-group is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-group is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-group subject157-references is-layout-constrained wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading\">Referencje<\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Ashmarin et al. (1995). <em>Rozw\u00f3j i neurobiologiczne skutki Semax.<\/em> Neuronauka i fizjologia behawioralna.<\/li>\n\n\n\n<li>Dolotov et al. (2006). <em>Indukowana przez Semax regulacja BDNF i NGF.<\/em> Raporty z biologii molekularnej.<\/li>\n\n\n\n<li>Andreeva et al. (2010). <em>Semax poprawia funkcje poznawcze w warunkach stresu.<\/em> Neuroscience Letters.<\/li>\n\n\n\n<li>Yarkova et al. (2013). <em>Neuroprotekcja przed niedokrwieniem poprzez szlaki melanokortyny.<\/em> Badania nad m\u00f3zgiem.<\/li>\n\n\n\n<li>Myasoedov et al. (2018). <em>Mechanizmy Semax w plastyczno\u015bci synaptycznej.<\/em> Frontiers in Neuroscience.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<p><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Przegl\u0105d naukowy na temat Semax, obejmuj\u0105cy szlaki melanokortyny, wzrost BDNF, neuroprotekcj\u0119 i obserwowany wp\u0142yw na funkcje poznawcze i reakcj\u0119 na stres.<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[10],"tags":[84,79,87,77,81,86,82,80,85,88,76,78,83],"class_list":["post-2163","post","type-post","status-publish","format-standard","hentry","category-journal","tag-aprendizagem","tag-bdnf","tag-cognicao","tag-isquemia","tag-mc4r","tag-mc5r","tag-melanocortinas","tag-neuromodulacao","tag-neuroprotecao","tag-peptideos-neurologicos","tag-plasticidade-neural","tag-semax","tag-stress-cognitivo"],"acf":[],"_links":{"self":[{"href":"https:\/\/subject157.com\/pl\/wp-json\/wp\/v2\/posts\/2163","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/subject157.com\/pl\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/subject157.com\/pl\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/subject157.com\/pl\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/subject157.com\/pl\/wp-json\/wp\/v2\/comments?post=2163"}],"version-history":[{"count":0,"href":"https:\/\/subject157.com\/pl\/wp-json\/wp\/v2\/posts\/2163\/revisions"}],"wp:attachment":[{"href":"https:\/\/subject157.com\/pl\/wp-json\/wp\/v2\/media?parent=2163"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/subject157.com\/pl\/wp-json\/wp\/v2\/categories?post=2163"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/subject157.com\/pl\/wp-json\/wp\/v2\/tags?post=2163"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}