Dihexa

What it is (in plain language)
- It is one of the most powerful nootropics known. While others merely 'stimulate' the brain, Dihexa helps to create new connections (synapses) between neurons. It was originally developed to reverse damage in diseases such as Alzheimer's, focussing on repairing the brain's infrastructure.

Why do you appear online so much
- It is often described as an industrial-grade 'mental fog cleaner'. Biohackers use it to increase mental processing speed and long-term memory, although it is an extremely powerful substance that requires caution.

How it is framed today (pragmatic view)
- 1) Evidence: Extraordinary pre-clinical results in neurodegeneration models. 2) Objective: Cognitive rehabilitation and extreme neuroplasticity. 3) Risk: As it promotes cell growth via HGF, it should be avoided by anyone with an oncological risk.

How to use this form
- Read the safety section on activating the c-Met receiver carefully.

- Quick profile (curated by Subject 157)
- Class: Nootropic
- Status: Verified
- Use case: Nootropic
- Route: Oral
- Tags: Oral|Transdermal|Brain
- Half-life: Unknown
- Start: Slow (Days)
- Duration: Sustained

- Mechanism (high level)
Angiotensin IV analogue. Potentiates HGF/c-Met signalling, inducing massive synaptogenesis and dendritic spinogenesis.

- Evidence (what the literature covers)
RESEARCH RANGE (Non-prescriptive):
Studied in doses of 10mg to 20mg.
Level of Evidence: C (Pre-clinical).

- Safety and harm-reduction (non-prescriptive)
Risks: Theoretical risk of oncogenesis (activation of growth factors).
Interactions: Unknown.

- References (anchors)
- Benoist, C. C. (2011) - Dihexa facilitates synaptogenesis and memory - https://doi.org/10.1124/jpet.111.182220 | PubMed:21990598
- Nguyen, L. (2021) - AngIV-analog dihexa and cognitive protection review - https://doi.org/10.3390/brainsci11111487 | PubMed:34827486

Note: Educational/research content. Does not constitute medical advice, diagnosis or prescription.